NDLI: CAN breathing oscillations reduce asthma medication?

Content Provider	IEEE Xplore Digital Library
Author	Mathur, M. Al-Jumaily, A.M. Ijpma, G. Alany, R.
Copyright Year	2011
Description	Author affiliation: Institute of Biomedical Technologies, Auckland University of Technology, Auckland, New Zealand (Mathur, M.; Al-Jumaily, A.M.; Ijpma, G.) \|\| School of Pharmacy University of Auckland Auckland, New Zealand (Alany, R.)
Abstract	Airway hyperresponsiveness and obstruction are the major characteristics of asthma. Current asthma treatments using anti-inflammatory agents and airway smooth muscle (ASM) relaxants are expensive, variable in effectiveness and are associated with several cardiovascular side effects. ASM behaviour in vitro has been studied by various researchers to possibly provide an explanation of its mechanical properties. Previous in vitro experiments conducted on ASM tissues suggest that length perturbations applied to contracted muscle result in a reduction in the contractile ability of the tissue. This study focuses on investigating the combined effects of bronchodilators and length oscillations on the dynamics of contracted ASM. Isolated porcine tracheal smooth muscle tissues are contracted using Acetylcholine. Isoproterenol (Iso), a β-agonist, is used as a bronchodilator to relax the contracted ASM. Our results suggest that the combined effect of Iso and breathing oscillations is noted to be greater than the added effects of Iso and breathing alone. We speculate that, when breathing is combined with Iso, breathing facilitates the detachment of actomyosin bridges, while Iso prevents further phosphorylation of myosin heads, inhibiting the binding of myosin to actin.
Starting Page	1
Ending Page	4
File Size	128609
Page Count	4
File Format	PDF
ISBN	9781424469987
e-ISBN	9781424470006
DOI	10.1109/MECBME.2011.5752051
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-02-21
Publisher Place	United Arab Emirates
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Bridges Strips Force Muscles In vitro Oscillators Analysis of variance
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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