NDLI: Three-dimensional flexible microprobe for recording the neural signal

Content Provider	IEEE Xplore Digital Library
Author	Chang-Hsiao Chen Shih-Chang Chuang Yu-Tao Lee Shih-Rung Yeh Yen-Chung Chang Da-Jeng Yao
Copyright Year	2009
Description	Author affiliation: Department of Life Sciences, National Tsing Hua University, Taiwan (Shih-Rung Yeh; Yen-Chung Chang) \|\| Institute of NanoEngineering and MicroSystems, National Tsing Hua University, Taiwan (Chang-Hsiao Chen; Shih-Chang Chuang; Yu-Tao Lee; Da-Jeng Yao)
Abstract	In this paper we have designed, fabricated and tested a novel three-dimensional (3D) flexible microprobe used for recording the neural signals of lateral giant (LG) on the escape system of America crayfish. We report an electrostatic actuation process to fold the planar probes to be the arbitrary orientations of 3D probes for neuroscience application. The batch assembly method based on electrostatic force techniques gave more simple fabrication compared with others. A flexible probe could reduce both the chronic inflammation response and material fracture when animal breathes or moves. Furthermore, the cortex corresponds to hypothetical cortical modules with mostly vertically organized layers of neurons. Therefore the 3D flexible probe suits to understand how the cooperative activity for different layers of neurons. Advisedly, we present a novel fabrication for 3D flexible probe by using parylene technology. The mechanical strength of the neural probe is strong enough to penetrate into a bio-gel. At the end, the flexible probe was used to record neural signals of LG cell from America crayfish.
Starting Page	278
Ending Page	281
File Size	988878
Page Count	4
File Format	PDF
ISBN	9781424455287
e-ISBN	9781424455300
DOI	10.1109/NANOMED.2009.5559071
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-10-18
Publisher Place	Taiwan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Microprobe Electric potential Biology Electrodes Micromechanical devices 3D Flexible Neuron PEG Parylene Three dimensional displays Pollution measurement Probes
Content Type	Text
Resource Type	Article

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