NDLI: Nonlinear model predictive control of fed-batch cultures of micro-organisms exhibiting overflow metabolism

Content Provider	IEEE Xplore Digital Library
Author	Santos, L.O. Dewasme, L. Hantson, A.-L. Vande Wouwer, A.
Copyright Year	2010
Description	Author affiliation: Department of Chemical Engineering, Faculty of Sciences and Technology, University of Coimbra, Portugal (Santos, L.O.) \|\| Service de Chimie et Biochimie Appliquées, Belgium (Hantson, A.-L.) \|\| Service d'Automatique, Université de Mons (UMONS), Boulevard Dolez 31, B-7000, Belgium (Dewasme, L.; Vande Wouwer, A.)
Abstract	Overflow metabolism characterizes cells strains that are likely to produce inhibiting metabolites resulting from an excess of substrate feeding and a saturated respiratory capacity. The critical substrate level separating the two different metabolic pathways is generally not well defined. This occurs for instance in Escherichia coli cultures with aerobic acetate formation. This paper considers the control problem of a lab-scale E. coli biomass production. A preliminary study is presented to access the application of a multivariable nonlinear model predictive control approach to maximize the biomass production. This strategy is tested by simulation and its performance to control the bioreactor system is evaluated with various objective cost functions, and in the presence of noise and dead-time on the acetate concentration measurement.
Starting Page	1608
Ending Page	1613
File Size	487680
Page Count	6
File Format	PDF
ISBN	9781424453627
ISSN	10851992
DOI	10.1109/CCA.2010.5611190
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-09-08
Publisher Place	Japan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Substrates Biomass Sugar Biological system modeling Noise Predictive models
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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