NDLI: Confronting a cardiovascular system model with heart rate and blood pressure data

Content Provider	IEEE Xplore Digital Library
Author	McSharry, P.E. McGuinness, M.J. Fowler, A.C.
Copyright Year	2005
Description	Author affiliation: Dept. of Eng. Sci., Oxford Univ. (McSharry, P.E.)
Abstract	The cardiovascular system may be investigated by observing fluctuations in the heart rate, blood pressure and rate of respiration. Its time evolution is governed by the baroreflex control mechanism, where the sympathetic and vagal nerves compete to increase and decrease the heart rate respectively. A nonlinear delay-differential equation model is constructed to describe this control mechanism and to explore the interactions between the heart rate and blood pressure. In this model, a time delay gives rise to the oscillations in the blood pressure known as Mayer waves. The model maintains an intrinsically stable heart rate in the absence of nervous control, and features baroreflex influence on both heart rate and peripheral resistance. The effect of respiratory sinus arrhythmia (RSA) is introduced using a sinusoidal driving component. Clinical recordings obtained by carefully controlling the rate and depth of respiration are used to test the suitability of the model for representing the complicated physiology of the cardiovascular system. The model is shown to be able to reproduce many of the empirical characteristics observed in these biomedical signals, including RSA, Mayer waves and synchronization. Key physiological parameters in the model, including the time delay and levels of sympathetic and vagal activity, could provide useful diagnostic information about the state of the cardiovascular system
Starting Page	587
Ending Page	590
File Size	379443
Page Count	4
File Format	PDF
ISBN	0780393376
DOI	10.1109/CIC.2005.1588169
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-09-25
Publisher Place	France
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Cardiovascular system Heart rate Blood pressure Baroreflex Delay effects Fluctuations Nonlinear equations Pressure control Immune system System testing
Content Type	Text
Resource Type	Article

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