NDLI: Echocardiographic imaging and quantification of myocardial perfusion based on interrupted contrast infusion

Content Provider	IEEE Xplore Digital Library
Author	Toledo, E. Lang, R.M. Collins, K.A. Williams, U. Lammertin, G. Bolotin, G. Mor-Avi, V.
Copyright Year	2004
Abstract	Echocardiographic quantification of myocardial perfusion, based on analysis of contrast replenishment foliowing destructive high-energy ultrasound impulses flash-echo). has multiple limitations. We present an alternative approach. based on analysis of conrrast replenishment afier brief interruptions of contrast infksion (ICI). Images were acquired in 8 isolated rabbit hearts at 3flow levels (baseline; 50% and 15%) during contrast infusion (Defnily) with flash-echo and, asfer ICI. Peak contrast inflow rate (PCIR) was calculated from ICI data and compared with Jash-echo dda. Clinical feasibiliQ was rested in 5 subjects with the ICI technique at rest and stress. In rabbit hearts, PCIR foilowed changes in coronary flow (p<0.0001) and had lower inter-measurement variability than the flashecho data. In humans, stress PCIR was 284±142% of resting value. ICI provides the basis for accurate and reproducible quuntification of myocurdial perfision and may consritule on alternative to the currently used techniques.
Starting Page	633
Ending Page	636
File Size	840776
Page Count	4
File Format	PDF
ISBN	0780389271
DOI	10.1109/CIC.2004.1443018
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-09-19
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Myocardium Heart Ultrasonic imaging Rabbits Steady-state Stress Humans Testing Image sequences Transducers
Content Type	Text
Resource Type	Article

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