NDLI: A computer modeling study of the localization of cardiac optical mapping at discrete depths below the tissue surface

Content Provider	IEEE Xplore Digital Library
Author	Ramshesh, V.K. Dumas, J.H. Knisley, S.B.
Copyright Year	2002
Description	Author affiliation: North Carolina Univ., Chapel Hill, NC, USA (Ramshesh, V.K.; Dumas, J.H.; Knisley, S.B.)
Abstract	Depth and radius of the region interrogated by cardiac optical mapping with a laser beam depend on photon travel inside the heart. It would be useful to limit range of depth and radius interrogated. Here the effects of a condensing lens to concentrate laser light at a target depth in the heart was modeled Monte Carlo computer simulations that incorporated a 0.55 NA lens in air and absorption and scattering of 488 nm laser light in 3-d cardiac tissue indicated the distribution of excitation light fluence. A subsequent computer simulation incorporating absorption and scattering of transmembrane voltage-sensitive fluorescence (669 nm) indicated locations in tissue from which fluorescence photons exiting the tissue surface originated The results indicate the heart can be interrogated at a discrete depth below the surface of myocardium with a condensing lens, although resolution is limited This may be applicable to laser scanner systems used for cardiac optical mapping.
Starting Page	317
Ending Page	319
File Size	200353
Page Count	3
File Format	PDF
ISBN	0780377354
ISSN	02766547
DOI	10.1109/CIC.2002.1166772
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-09-22
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Optical computing Optical scattering Laser modes Heart Lenses Computer simulation Absorption Light scattering Particle scattering Fluorescence
Content Type	Text
Resource Type	Article

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