NDLI: Ventricular fibrillation in rats with cardiac fibrosis

Content Provider	IEEE Xplore Digital Library
Author	Marak, S. de Jongh, A.L.
Copyright Year	2002
Description	Author affiliation: Univ. of Memphis, TN, USA (Marak, S.; de Jongh, A.L.)
Abstract	Previous studies have shown that administration of angiotensin II (Ang II) causes atrial and ventricular fibrosis in rats, as is found in patients with chronic heart failure. We hypothesize that fibrosis creates a substrate that promotes the induction of ventricular fibrillation (VF). Fourteen, eight-week old, Sprague-Dawley rats were studied. Eleven received a four-week treatment of Ang II (9 /spl mu/g/hr) from an implanted mini-pump. After treatment, the chest was opened, and 50 Hz stimulation at a strength of three times the pacing threshold was applied across the atria and ventricles for 2.5, 5, and 10 s. VF was more inducible in treated rats (6 of 11) than untreated rats (0 of 3, P < 0.05). Three of 12 VF episodes were sustained (> 10 s) while the remaining VF episodes were nonsustained (> 30 ms and < 10 s) after stimulation ended. Our results suggest that cardiac fibrosis induced by Ang II treatment creates a substrate for sustained VF.
Starting Page	249
Ending Page	250
File Size	192209
Page Count	2
File Format	PDF
ISBN	0780377354
ISSN	02766547
DOI	10.1109/CIC.2002.1166754
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-09-22
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Fibrillation Rats Animals Computerized monitoring Electrocardiography Heart rate Microscopy Myocardium Hypertension Morphology
Content Type	Text
Resource Type	Article

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