NDLI: Measurement of Relative Brain Atrophy in Neurodegenerative Diseases

Content Provider	IEEE Xplore Digital Library
Author	Abdala, D.D. Wangenheim, Av.
Copyright Year	2006
Description	Author affiliation: Dept. of Comput. Sci. & Stat., Univ. Fed. de Santa Catarina, Florianopolis (Abdala, D.D.; Wangenheim, Av.)
Abstract	This paper presents a new methodology to be used in measuring brain atrophy on imaging exams of patients with neurodegenerative diseases. The methods foresee the usage of a mean brain that serves as a reference volume. Color maps were created following a cold-hot color scheme where highlighted regions of atrophy based on the standard deviation and mean values voxel-wise of the mean brain. Direct measures of the atrophy grade were obtained by statistical comparisons between the mean brain volume and regions identified as atrophied. The proposed method was evaluated using 35 patients, 16 had been previously diagnosed as Alzheimer cases, 7 as MCI, 2 as vascular dementia and 10 as complainers. The mean brain used in this study was created using affine transformations to drive the necessary volume registration and were composed of healthy patients. All diagnostics followed a neuropsychological protocol
Starting Page	365
Ending Page	370
File Size	457103
Page Count	6
File Format	PDF
ISBN	0769525171
ISSN	10637125
DOI	10.1109/CBMS.2006.112
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-06-22
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Atrophy Diseases Dementia Protocols Anatomy Laboratories Telemedicine Computer science Statistics Volume measurement
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Computer Science Applications

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