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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Giaever, I. Keese, C.R. |
| Copyright Year | 1994 |
| Description | Author affiliation: Sch. of Sci., Rensselaer Polytech. Inst., Troy, NY, USA (Giaever, I.; Keese, C.R.) |
| Abstract | Summary form only given as follows: Great advances have been made in quantifying biochemical and physiological activities in cultured cells. It has, however been difficult to quantify changes of cell morphology. A method has now been developed that can continuously and non-invasively track morphological changes of adherent cells and provide data from both sparse and confluent cultures. In electric cell-substrate impedance sensing (ECIS), cells are cultured on small (0.001 cm/sup 2/) gold film electrodes whose impedance is measured with a 1 micro amp current, generally at 4,000 Hz; normal tissue culture medium serves as the electrolyte. When cells attach and spread on these electrodes, their essentially insulating membranes constrain the current and force it to flow beneath and between the cells. This results in large impedance changes. Furthermore, alterations in cell morphology gives rise to variations in impedance that can be numerically analyzed to report levels of cell motility and, indirectly, cell metabolism. The approach is exceedingly sensitive and is capable of detecting changes in cell morphology on the order of nanometers, well below the resolution of an optical microscope.< |
| File Size | 55095 |
| File Format | |
| ISBN | 0780320506 |
| DOI | 10.1109/IEMBS.1994.412159 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 1994-11-03 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Impedance measurement Morphology Cells (biology) Electrodes Optical microscopy Biomedical monitoring Insulation life Gold Current measurement Electric variables measurement |
| Content Type | Text |
| Resource Type | Article |
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