NDLI: Measurement of contractile characteristics from isolated heart cells using a miniaturized force transducer system

Content Provider	IEEE Xplore Digital Library
Author	Lin, G. Pister, K.S.J. Roos, K.P.
Copyright Year	1994
Description	Author affiliation: Dept. of Electr. Eng., California Univ., Los Angeles, CA, USA (Lin, G.)
Abstract	A custom-designed microelectromechanical force transducer, with a volume less than one cubic millimeter, is being developed to quantify forces generated in isolated, contracting cardiac muscle cells in order to elucidate the physiology of muscle. A single heart cell is attached to flexible, hinged polysilicon plates submerged in a nutrient solution. As the cell contracts, the plates bend, and the contractile force can be measured based on the known spring constant of the plate. The amount of deflection is measured by piezoresistive, ion-implanted strain gauges placed at the base of the plates. Prototype structures have been fabricated and have been mechanically tested using metal probes. The authors have demonstrated that living rat heart cells can be attached to polysilicon using a commercial silicone sealant. They have also observed that polysilicon is an inert material when exposed to cardiac cells and their saline environment and has no detectable effect on the cells themselves.
Starting Page	1017
Ending Page	1018
File Size	198170
Page Count	2
File Format	PDF
ISBN	0780320506
DOI	10.1109/IEMBS.1994.415301
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1994-11-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Heart Muscles Force measurement Strain measurement Transducers Physiology Contracts Springs Piezoresistance Prototypes
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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