NDLI: Cholinergic and adrenergic modulation of ionic membrane currents in a rabbit SA node cell model

Content Provider	IEEE Xplore Digital Library
Author	Demir, S.S. Clark Jr., J.W. Giles, W.R.
Copyright Year	1994
Description	Author affiliation: Dept. of Electr. & Comput. Eng., Rice Univ., Houston, TX, USA (Demir, S.S.; Clark, J.W., Jr.; Giles, W.R.)
Abstract	We have modified our Hodgkin-Huxley (HH)-type compartmental model of the rabbit sinoatrial node (SAN) cell, to show the effects of cholinergic and adrenergic modulation on certain ionic membrane currents. This study centers on the direct and indirect effects of bath application of acetylcholine (ACh) in the presence or absence of isoprenaline (ISO). Specifically, the direct effect of ACh is on the muscarinic G-protein mediated K/sup +/ current I/sub K,ACh/, while the indirect effect is mediated by the second messenger cyclic adenosine monophosphate (cAMP) which modulates four specific membrane currents: the hyperpolarization-activated inward current (I/sub f/), the long-lasting Ca/sup 2+/ current (I/sub CaL/), the delayed-rectifier K/sup +/ current (I/sub K/) and the Na/sup +/-K/sup +/ pump current (I/sub NaK/). The model also includes material balances on Na/sup +/, Ca/sup 2+/, K/sup +/ and cAMP. The resulting model is capable of mimicking the response of the SAS cell to bath applications of these chemical agents (i.e. inhibitory effects of ACh and the excitatory effects of ISO upon the cycle length). In addition, the model is capable of mimicking the phase sensitivity of the SAN cell in response to both single and periodically-applied ACh stimuli in either the presence and absence of steady background levels of ISO. In these studies, the "ACh stimuli" used represent the local change in ACh concentration produced by the stimulation of a cluster of parasympathetic nerve terminal endings that surround individual pacemaking cells within the SA nodal region of the rabbit heart. Our simulation results for the single cell indicate that the model has a high degree of predictive value in that it can mimic data obtained from multicellular preparations, as well as provide biophysically based explanations for the well known phase-sensitivity of cardiac pacemaker cells to both single and periodically applied ACh stimuli.<>
Starting Page	728
Ending Page	729
File Size	207934
Page Count	2
File Format	PDF
ISBN	0780320506
DOI	10.1109/IEMBS.1994.415263
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1994-11-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Biomembranes ISO Rabbits Storage area networks Predictive models Delay effects Synthetic aperture sonar Chemicals Heart Pacemakers
Content Type	Text
Resource Type	Article

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