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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Kendall, M.A.F. Wrighton Smith, P.J. Bellhouse, B.J. |
| Copyright Year | 2000 |
| Description | Author affiliation: Dept. of Eng., Oxford Univ., UK (Kendall, M.A.F.) |
| Abstract | This paper describes investigations into the impact of model micro-particles into excised human skin. This work is aimed at optimising a unique form of transdermal drug delivery, based on PowderJect/sup (R)/ devices. These devices work by accelerating drugs in micro-particle form to a velocity at which they will enter the skin. Not only are PowderJect/sup (R)/ devices painless and needle-free; by the manipulation of penetration depth, existing therapeutic compounds can be made to work much more effectively. A research device was designed to deliver particles to the skin at conditions with nominally uniform velocities. Glass, polystyrene and steel micro-spheres were used to simulate drug payloads. The results of these investigations show that penetration depth into skin is a function of particle density, radius and entry velocity. This relationship provides a criterion for the optimal selection of particle parameters and entry velocity to target specific layers within the skin. The experimental data is compared to both a theoretical and an empirical model with good agreement. |
| Starting Page | 1621 |
| Ending Page | 1624 |
| File Size | 510643 |
| Page Count | 4 |
| File Format | |
| ISBN | 0780364651 |
| ISSN | 1094687X |
| DOI | 10.1109/IEMBS.2000.900385 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2000-07-23 |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Skin Drug delivery Acceleration Payloads Pistons Humans Glass Steel Pharmaceutical technology Vaccines |
| Content Type | Text |
| Resource Type | Article |
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