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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Grill, W.M. Richardson, A.G. McIntyre, C.C. |
| Copyright Year | 2000 |
| Description | Author affiliation: Dept. of Biomed. Eng., Case Western Reserve Univ., Cleveland, OH, USA (Grill, W.M.) |
| Abstract | The excitation and conduction properties of computer-based cable models of mammalian motor nerve fibers incorporating three different myelin representations were compared. The three myelin representations were a perfectly insulating single cable (model A), a finite impedance single cable (model B), and a finite impedance double cable (model C). Extracellular stimulation of the three models was used to study strength-duration, current-distance (I-X), conduction velocity (CV) properties. All three models had a chronaxie time (Tch) that was within the experimental range. Models B and C had increased threshold current as compared to model A, but each model had a slope to the I-X relationship that matched experimental results. Model B had a CV that matched experimental data while the CV of models A and C were above and below the experimental range, respectively. These results indicate that the presence of a finite impedance myelin sheath does influence the excitation properties of nerve fiber models and must be considered when using models for design of neural stimulation paradigms. |
| Starting Page | 1605 |
| Ending Page | 1607 |
| File Size | 286232 |
| Page Count | 3 |
| File Format | |
| ISBN | 0780364651 |
| ISSN | 1094687X |
| DOI | 10.1109/IEMBS.2000.900380 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2000-07-23 |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Myelin Nerve fibers Extracellular Impedance Cable shielding Circuits Resistors Biomembranes Cable insulation Threshold current |
| Content Type | Text |
| Resource Type | Article |
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