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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Calhoun, V.D. Adali, T. Kraut, M. Rivkin, P. Pearlson, G. |
| Copyright Year | 1998 |
| Description | Author affiliation: Div. of Psychiatric Neuro-Imaging, Johns Hopkins Univ., Baltimore, MD, USA (Calhoun, V.D.) |
| Abstract | Functional MRI is a technique capable of providing spatial and temporal information about the brain's hemodynamics. It has been observed that the onset of observed signal changes can vary across regions exhibiting activation. The authors have developed a method for extracting information about these timing differences and for observing the temporal-spatial distribution of the blood response by, characterizing a typical hemodynamic response (HR) to a single flash of light repeated at 30 s intervals. They anatomically locate voxels in the primary visual cortex, a region located along the calcarine sulcus, which is the main terminus of the geniculocortical visual pathways. This average response profile is correlated with the data, producing a map of "active" voxels. Next, the authors explore the distribution of lags by shifting the HR, correlating this signal with the data, and producing another map. They observed increased activation in non-primary visual cortex as the lag was increased to 2-3 s. These results can be most effectively displayed in a time lapse movie. The described technique provides a way of determining varying hemodynamic lag times and partitioning "activated" regions in time. It also clearly demonstrates that these time lags do differ spatially. |
| Starting Page | 2124 |
| Ending Page | 2127 |
| File Size | 746178 |
| Page Count | 4 |
| File Format | |
| ISBN | 0780351649 |
| ISSN | 1094687X |
| DOI | 10.1109/IEMBS.1998.747028 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 1998-11-01 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Visualization Hemodynamics Magnetic resonance imaging Psychology Data mining Neuroimaging Radiology Timing Blood Motion pictures |
| Content Type | Text |
| Resource Type | Article |
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