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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Bajaj, V. Madan, A.K. |
| Copyright Year | 1995 |
| Description | Author affiliation: Dept. of Pharm., Delhi Univ., India (Bajaj, V.; Madan, A.K.) |
| Abstract | Normally nonadductible endocytic drugs (NNAED) such as vitamin E and famotidine were successfully included in urea in the presence of a rapidly adductible endocyte (RAE). Formation of urea based conclusion compounds of vitamin E and famotidine was confirmed by IR spectroscopy, DTA, polycrystalline X-ray diffraction and calorimetric analysis. Weakening of the hexagonal lattice of host urea owing to distortion caused by the presence of highly substituted NNAED was exploited for the enhancement of dissolution rate of famotidine and vitamin E. The simultaneous accomplishment of improved content uniformity and an enhanced dissolution rate, due to ease in dispersion of the drug at a molecular level offer this technique a vast potential as an alternative to conventional solid dispersions. |
| File Size | 254254 |
| File Format | |
| ISBN | 078032711X |
| DOI | 10.1109/RCEMBS.1995.533032 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 1995-02-15 |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Lattices Drugs Solid state circuits Temperature Educational institutions Spectroscopy X-ray diffraction Pharmaceuticals Solvents Methanol |
| Content Type | Text |
| Resource Type | Article |
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