NDLI: Axon radius measurements in vivo from diffusion MRI: a feasibility study

Content Provider	IEEE Xplore Digital Library
Author	Alexander, D.C.
Copyright Year	2007
Description	Author affiliation: Univ. Coll. London, London (Alexander, D.C.)
Abstract	This paper investigates the feasibility of using diffusion MRI to measure axon-cell dimensions in the white matter of live subjects. A simple geometric model of white-matter tissue provides an expression that relates the axon radius to the diffusion MRI signal. The aim is to determine the accuracy and precision with which we can estimate this potentially important new biomarker. Precision and accuracy depend critically on the acquisition protocol. The paper proposes a general strategy to optimize the experiment design of in-vivo diffusion MRI experiments. The applicability of the design optimization extends well beyond the current work to optimizing the acquisition for any model of the diffusion process. Simulation experiments and results suggest feasibility of measuring larger axon radii in vivo on modern MRI scanners using the optimized acquisition schemes, but that higher gradient strengths are required to measure smaller axons.
Starting Page	1
Ending Page	8
File Size	354467
Page Count	8
File Format	PDF
ISBN	9781424416301
ISSN	15505499
DOI	10.1109/ICCV.2007.4409141
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-10-14
Publisher Place	Brazil
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Nerve fibers In vivo Magnetic resonance imaging Biomarkers Design optimization Particle measurements Microstructure Solid modeling Displacement measurement Tensile stress
Content Type	Text
Resource Type	Article
Subject	Computer Vision and Pattern Recognition Software

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