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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Pacureanu, A. Rongqin Ke Mignardi, M. Nilsson, M. Wahlby, C. |
| Copyright Year | 2014 |
| Description | Author affiliation: Dept. of Biochem. & Biophys., Stockholm Univ., Stockholm, Sweden (Rongqin Ke; Mignardi, M.; Nilsson, M.) || Centre for Image Anal., Uppsala Univ., Uppsala, Sweden (Pacureanu, A.; Wahlby, C.) |
| Abstract | Profiling of gene expression is necessary to study the function of cells, organs and ultimately organisms, in health and disease. However, the currently available mRNA sequencing methods are limited to homogenized tissue samples. Therefore, the obtained information represents either the average expression profile of the full tissue sample or expression profiles from isolated single cells extracted from the tissue. We have developed an image-based approach for sequencing of mRNA fragments directly in fixed tissue. As opposed to current routine techniques, this allows gene expression profiling in relation to the preserved morphological and spatial information of cells and tissue. We present here the details of the image analysis and demonstrate its application to breast cancer tissue samples. |
| Starting Page | 286 |
| Ending Page | 289 |
| File Size | 1078309 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781467319614 |
| DOI | 10.1109/ISBI.2014.6867865 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2014-04-29 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Sequential analysis Gene expression Image analysis RNA Fluorescence Probes Image segmentation gene expression mapping gene sequencing histopathology cancer tissue |
| Content Type | Text |
| Resource Type | Article |
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