NDLI: A framework for the detection of acute renal rejection with dynamic contrast enhanced magnetic resonance imaging

Content Provider	IEEE Xplore Digital Library
Author	Farag, A. El-Baz, A. Yuksel, S.E. El-Ghar, M.A. Eldiasty, T.
Copyright Year	2006
Description	Author affiliation: Dept. of ECE, Louisville Univ., KY (Farag, A.; El-Baz, A.; Yuksel, S.E.)
Abstract	Acute rejection is the most common reason of graft failure after kidney transplantation, and early detection is crucial to survive the transplanted kidney function. In this paper we introduce a new approach for the automatic classification of normal and acute rejection transplants from dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). The proposed algorithm consists of three main steps; the first step isolates the kidney from the surrounding anatomical structures by evolving a deformable model based on two density functions; the first function describes the distribution of the gray level inside and outside the kidney region and the second function describes the prior shape of the kidney. In the second step, nonrigid-registration algorithms are employed to account for the motion of the kidney due to patient breathing, and finally, the perfusion curves that show the transportation of the contrast agent into the tissue are obtained from the cortex and used in the classification of normal and acute rejection transplants. Applications of the proposed approach yield promising results that would, in the near future, replace the use of current technologies such as nuclear imaging and ultrasonography, which are not specific enough to determine the type of kidney dysfunction
Starting Page	418
Ending Page	421
File Size	1250976
Page Count	4
File Format	PDF
ISBN	078039576X
DOI	10.1109/ISBI.2006.1624942
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-04-06
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Magnetic resonance imaging Biopsy Image segmentation Image edge detection Immune system Anatomical structure Deformable models Density functional theory Shape Transportation
Content Type	Text
Resource Type	Article

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