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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Rogan, P.K. Knoll, J.H.M. |
| Copyright Year | 2004 |
| Description | Author affiliation: Childrens Mercy Hospital & Clinics, Missouri Univ., Kansas City, MO, USA (Rogan, P.K.; Knoll, J.H.M.) |
| Abstract | Precise delineation of rearranged chromosomes in genetic diseases and cancer by fluorescence in situ hybridization can identify the primary etiologies of these disorders. We present a novel approach for defining these abnormalities based on sequential fluorescence in situ hybridization (FISH) of arrays of single copy genomic probes. These arrays consist of sequence-defined synthetic DNA products that can be produced at significantly higher genomic densities than recombinant probes used in conventional FISH. Single copy FISH (scFISH) probes are 50-100 fold shorter than those used for conventional FISH. With scFISH, chromosome abnormalities can be determined at a resolution equivalent to molecular genetic approaches such as Southern analysis. We show how line minimization and bracketing techniques can be used to select probes to optimize strategies for translocation breakpoint determination. |
| Starting Page | 73 |
| Ending Page | 76 |
| File Size | 614013 |
| Page Count | 4 |
| File Format | |
| ISBN | 0780383885 |
| DOI | 10.1109/ISBI.2004.1398477 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2004-04-18 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Biological cells Fluorescence Marine animals Probes Genetics Genomics Bioinformatics Diseases Cancer DNA |
| Content Type | Text |
| Resource Type | Article |
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