NDLI: Power spectral analysis of heart rate variability in ryanodine receptor type 3 knockout mice

Content Provider	IEEE Xplore Digital Library
Author	Kihwan Ju Kuwaki, T. Takeshima, H. Iino, M. Kumada, M.
Copyright Year	1997
Description	Author affiliation: Dept. of Physiol., Tokyo Univ., Japan (Kihwan Ju)
Abstract	The role of ryanodine receptor type 3 (RyR-3) in the autonomic control of heart rate (HR) was studied by recording electrocardiogram (ECG) in conscious mutant mice totally lacking RyTR-3 (RyR-3 knockout mice) and their wild-type littermates. In RyR-3 knockout mice. HR was not significantly altered but its variability, evaluated by the coefficient of variance of R-R intervals of ECG, was significantly reduced as compared to that of wild-type mice. Further, sympathetic and vagal control of HR were assessed on the basis of the power spectrum of R-R variability calculated by the autoregressive analysis modified by the maximum entropy method. Low (LF) and high frequency components (HF) and their power, either real values or normalized by total power, were calculated from the power spectrum. In RyR-3 knockout mice, normalized LF power and LF/HF ratio, representing cardiac sympathetic activity and sympatho-vagal balance, respectively, were significantly smaller than in wild-type mice. Additionally, total power and LF power tended to be smaller. These results support the view that insufficient sympathetic control of HR and altered sympatho-vagal balance underlies reduction of HR variability in RyR-3 knockout mice. In conclusion, RyR-3 participates in the physiological control of HR by the cardiac nerve in conscious mice.
Starting Page	7
Ending Page	10
File Size	322699
Page Count	4
File Format	PDF
ISBN	0780338693
ISSN	10864105
DOI	10.1109/SBEC.1997.583202
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1997-04-04
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Spectral analysis Heart rate variability Mice Heart rate Electrocardiography Hafnium Frequency Muscles Entropy Calcium
Content Type	Text
Resource Type	Article

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