NDLI: Profiling the Nanoparticles Associated Protein-protein Interactions

Content Provider	IEEE Xplore Digital Library
Author	Wei-Chen Liao Nai-Kuei Huang
Copyright Year	2009
Abstract	To explore the nanoparticles-dependent signaling pathways is a rapidly growing research field. Here, we globally elucidate the regulation modules of cellular molecules by using graph-based representation of complex networks. We have packed some useful bioinformatics methods (Matlab Simbiology and Pathway Studio) into an integrated system for graph-based representation and complex networks modeling. Here, this system is applied to the public literature and microarray database of nanoparticles and try to find out nanoparticles related genetic regulatory pathways. By comparing to different model organism system (bacteria, mice, cell line), we will establish a multidimensional (protein cellular location, time course expression pattern and chemicals interacting profiles) secondary database. The value added database will uncover some new relationships between genes and nanoparticles and provide useful information for the modeling of nanoparticles cellular regulatory pathway in an interactive form. The new modeling approaches should serve as a research platform to find protein candidates for nanoparticles associated diseases and provides a possible cue to improve the bio-chemo-informatics analyses on gene expression and molecular pharmacology.
Starting Page	382
Ending Page	385
File Size	458915
Page Count	4
File Format	PDF
ISBN	9780769536569
DOI	10.1109/BIBE.2009.54
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-06-22
Publisher Place	Taiwan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Nanoparticles Proteins Mathematical model Databases Complex networks Cellular networks Bioinformatics Genetics Organisms Microorganisms complex networks nanoparticles bioinformatics
Content Type	Text
Resource Type	Article

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