NDLI: Understanding homeostatic dynamics of the HPA axis using a glucocorticoid pulsatile model

Content Provider	IEEE Xplore Digital Library
Author	Kosmides, A. Scheff, J.D. Calvano, S.E. Lowry, S.F. Androulakis, I.
Copyright Year	2011
Description	Author affiliation: Department of Surgery, RWJ Medical School, Piscataway, NJ, USA (Calvano, S.E.; Lowry, S.F.) \|\| Department of Biomedical Engineering, Rutgers University, Piscataway, NJ, USA (Kosmides, A.; Scheff, J.D.; Androulakis, I.)
Abstract	In silico models are often constructed to aid in the understanding of disease and the production of relevant intervention strategies. Several existing models study the acute inflammatory response, which is of importance in multiple organ dysfunction syndrome and sepsis, both of which have high mortality rates. However, no current model of inflammation considers the unique secretory dynamics of cortisol whose secretion has been hypothesized to drive rhythms in key components of the inflammatory response. Cortisol is secreted in a pulsatile and circadian manner, and these characteristics vary with stress. These variations cause both changes in the dynamics of the inflammatory response because they drive the variability in cytokine and hormone production as well as intrinsically relay important information about the system. Changes in feedback within the hypothalamic-pituatary-adrenal axis alter the pulsatile pattern of cortisol secretion, leading to a propagation of events downstream. Here, we build on a previous model of the acute inflammatory response by presenting a method for representing the pulsatile secretion of cortisol in which pulses are the output of a continuous system. Effects on the homeostatic dynamics of the hypothalamic-pituatary-adrenal axis are analyzed as well as its potential in a full inflammatory model.
Starting Page	1
Ending Page	2
File Size	563121
Page Count	2
File Format	PDF
ISBN	9781612848273
ISSN	1071121X
e-ISBN	9781612848280
DOI	10.1109/NEBC.2011.5778632
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-04-01
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Mathematical model Stress Plasmas Timing Biological system modeling Oscillators Biochemistry
Content Type	Text
Resource Type	Article
Subject	Chemical Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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