NDLI: Detection of hyaluronic acid on a functionalized surface enhanced raman scattering substrate

Content Provider	IEEE Xplore Digital Library
Author	Figueroa, M. Pourrezaei, K. Tyagi, S.
Copyright Year	2011
Description	Author affiliation: Drexel University, 3141 Chestnut St, Philadelphia, PA 19104, USA (Figueroa, M.; Pourrezaei, K.; Tyagi, S.)
Abstract	Hyaluronic acid (HA) is a high molecular weight glycosaminoglycan found in the extracellular matrix and joints in the body. Elevated levels in the serum are associated with liver disease so detection at concentrations in the microgram per liter range is useful for monitoring cirrhosis progression. Conventional methods can measure HA in this range but they take several days and require multiple preparation steps. Surface-enhanced Raman scattering (SERS) could be an alternative as it yields specific signatures stemming from molecular vibrations and has been shown to provide large enhancement factors. However, due to its intrinsic negative charge HA does not readily adsorb on metallic surfaces. To overcome this, a functionalized SERS substrate was developed to immobilize HA. A cysteamine self-assembling monolayer in the trans conformation allows the HA carboxyl group to attach to the ligand's amine group. The SERS signal can be used to monitor the concentration of cysteamine trans conformers in order to optimize HA attachment. In addition, SERS analysis shows an increase in HA Raman band intensity when immobilized to the substrate as compared to free HA on the substrate. Correlations between HA concentration and Raman band intensity are also discussed.
Starting Page	1
Ending Page	2
File Size	118191
Page Count	2
File Format	PDF
ISBN	9781612848273
ISSN	1071121X
e-ISBN	9781612848280
DOI	10.1109/NEBC.2011.5778594
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-04-01
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Substrates Nanoparticles Raman scattering Silver Ink Monitoring Carbon
Content Type	Text
Resource Type	Article
Subject	Chemical Engineering

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