NDLI: Subnanosecond Electric Pulses Cause Membrane Permeabilization and Cell Death

Content Provider	IEEE Xplore Digital Library
Author	Shu Xiao Siqi Guo Nesin, V. Heller, R. Schoenbach, K.H.
Copyright Year	1964
Abstract	Subnanosecond electric pulses (200 ps) at electric field intensities on the order of 20 kV/cm cause the death of B16.F10 murine melanoma cells when applied for minutes with a pulse repetition rate of 10 kHz. The lethal effect of the ultrashort pulses is found to be caused by a combination of thermal effects and electrical effects. Studies on the cellular level show increased transport across the membrane at much lower exposure times or number of pulses. Exposed to 2000 pulses, NG108 cells exhibit an increase in membrane conductance, but only allow transmembrane currents to flow, if the medium is positively biased with respect to the cell interior. This means that the cell membrane behaves like a rectifying diode. This increase in membrane conductance is a nonthermal process, since the temperature rise due to the pulsing is negligible.
Sponsorship	IEEE Engineering in Medicine and Biology Society
Page Count	7
File Size	529912
Starting Page	1239
Ending Page	1245
File Format	PDF
ISSN	00189294
Volume Number	58
Issue Number	5
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-05-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Biomembranes Temperature measurement Electric fields Plasma temperature Electrodes Optical fiber cables Temperature sensors subnanosecond pulses Cell death current rectifying permeabilization pulsed electric field
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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