NDLI: Microcirculation volumetric flow assessment using high-resolution, contrast-assisted images

Content Provider	IEEE Xplore Digital Library
Author	Chih-Kuang Yeh Sheng-Yi Lu Yung-Sheng Chen
Copyright Year	1986
Abstract	To improve the resolution of contrast-assisted imaging systems, we previously developed a 25-MHz microbubbles-destruction/replenishment imaging system with a spatial resolution of 160 X 160 mum. The goal of the present study was to propose a new approach for functionally evaluating the microvascular volumetric blood flow based on this high-frequency, ultrasound imaging system. The approach includes locating the perfusion area and estimating the blood flow velocity therein. Because the correlation changes between before and after microbubble destruction in two adjacent images, a correlated-based approach was introduced to detect the blood perfusion area. We also have derived a new sigmoid-based model for characterizing the microbubbles replenishment process. Two parameters derived from the sigmoid-based model - the rate constant and inflection time - were adopted to evaluate the blood flow velocity. This model was validated using both simulations and in vitro experiments for mean flow velocities ranging from 1 to 10 mm/s, which showed that the model was in good agreement with simulated and measured microbubble-replenishment time-intensity curves. The results indicate that the actual flow velocity is highly correlated with the estimates of the rate constant and the reciprocal of the inflection time. B-mode imaging experiments for mean flow velocities ranging from 0.4 to 2.1 mm/s were used to assess the volumetric flow in the microcirculation. The results indicated the high correlation between the actual volumetric flow rate and the product of the estimated perfusion area and rate constant, and the reciprocal of the inflection time. We also found that the boundary of the microbubble destruction volume significantly affected estimations of the flow velocity. The perfusion area can be located, and the corresponding flow velocity can be estimated simultaneously in a one-stage, microbubble-destruction/replenishment process, which makes the assessment of the volumetric blood flow in the microcirculation feasible using a real-time, high-frequency ultrasound system.
Page Count	10
File Size	1032147
Starting Page	74
Ending Page	83
File Format	PDF
ISSN	08853010
Volume Number	55
Issue Number	1
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrasonic imaging Spatial resolution High-resolution imaging Blood flow Neoplasms Cancer Image resolution In vitro Biomedical measurements Fluid flow measurement
Content Type	Text
Resource Type	Article
Subject	Acoustics and Ultrasonics Instrumentation Electrical and Electronic Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Contrast medium assisted fluid flow measurements

Volumetric blood flow estimation using dynamic three-dimensional ultrasound color flow imaging

Detection and Tracking of Multiple Microbubbles in Ultrasound B-Mode Images

High frequency color flow imaging of the microcirculation

Test phantoms for color flow imaging systems [biomedical ultrasonics]

Photoacoustic Flow Measurements with Gold Nanoparticles

Contrast response analysis for medical ultrasound imaging

Ultrasound methods for investigating the non-Newtonian characteristics of whole blood

Three-dimensional motion measurements using feature tracking

Microcirculation volumetric flow assessment using high-resolution, contrast-assisted images

Similar Documents

Contrast medium assisted fluid flow measurements

Volumetric blood flow estimation using dynamic three-dimensional ultrasound color flow imaging

Detection and Tracking of Multiple Microbubbles in Ultrasound B-Mode Images

High frequency color flow imaging of the microcirculation

Test phantoms for color flow imaging systems [biomedical ultrasonics]

Photoacoustic Flow Measurements with Gold Nanoparticles

Contrast response analysis for medical ultrasound imaging

Ultrasound methods for investigating the non-Newtonian characteristics of whole blood

Three-dimensional motion measurements using feature tracking

Microcirculation volumetric flow assessment using high-resolution, contrast-assisted images