NDLI: Lethal Effect of Electric Fields on Isolated Ventricular Myocytes

Content Provider	IEEE Xplore Digital Library
Author	de Oliveira, P.X. Bassani, R.A. Bassani, J.W.M.
Copyright Year	1964
Abstract	Defibrillator-type shocks may cause electric and contractile dysfunction. In this study, we determined the relationship between probability of lethal injury and electric field intensity (E) in isolated rat ventricular myocytes, with emphasis on field orientation and stimulus waveform. This relationship was sigmoidal with irreversible injury for E > 50 V/cm. During both threshold and lethal stimulation, cells were twofold more sensitive to the field when it was applied longitudinally (versus transversally) to the cell major axis. For a given E, the estimated maximum variation of transmembrane potential ( DeltaV _max) was greater for longitudinal stimuli, which might account for the greater sensitivity to the field. Cell death, however, occurred at lower maximum DeltaV _max values for transversal shocks. This might be explained by a less steep spatial decay of transmembrane potential predicted for transversal stimulation, which would possibly result in occurrence of electroporation in a larger membrane area. For the same stimulus duration, cells were less sensitive to field-induced injury when shocks were biphasic (versus monophasic). Ours results indicate that, although significant myocyte death may occur in the E range expected during clinical defibrillation, biphasic shocks are less likely to produce irreversible cell injury.
Sponsorship	IEEE Engineering in Medicine and Biology Society
Page Count	8
File Size	265993
Starting Page	2635
Ending Page	2642
File Format	PDF
ISSN	00189294
Volume Number	55
Issue Number	11
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-11-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electric shock Injuries Defibrillation Biomembranes Myocardium Electrodes Fibrillation Rabbits Electric potential Protocols irreversible cell injury Calcium overload defibrillation electric field stimulation electropermeabilization
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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