NDLI: Evaluation of ultrasound tissue damage based on changes in image echogenicity in canine kidney

Content Provider	IEEE Xplore Digital Library
Author	Jongbum Seo Tran, B.C. Hall, T.L. Fowlkes, J.B. Abrams, G.D. O'Donnell, M. Cain, C.A.
Copyright Year	1986
Abstract	Sufficiently high intensity ultrasound can create hyperechoic regions in an ultrasound image due to local bubble generation. We explore the link between the temporal extent of these hyperechoic regions and tissue damage caused by ultrasound therapy. The decay rate of increased echogenicity from the focal zone in insonated live exteriorized canine kidney was quantified and correlated to the spatial extent of tissue damage. The decay half-time, t/sub half/, defined as the time for echogenicity enhancement to decay by a factor of 2, was observed in all cases to be greater than 41 s in spatial zones in which extensive histological damage was observed. In cases in which the measured t/sub half/ was less than 11 s, the damage was limited to minor hemorrhage, or it was not detected. These t/sub half/ discrimination boundaries of 41 and 11 s were not statistically different for cases in which contrast agent was used to enhance therapeutic efficiency. This was true even though contrast agent infusion significantly reduced the therapy pulse duration threshold for damage production.
Page Count	10
File Size	2384394
Starting Page	1111
Ending Page	1120
File Format	PDF
ISSN	08853010
Volume Number	52
Issue Number	7
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-07-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrasonic imaging Tissue damage Medical treatment Surgery Temperature distribution In vivo Ultrasonic variables measurement Animals Student members Hemorrhaging
Content Type	Text
Resource Type	Article
Subject	Acoustics and Ultrasonics Instrumentation Electrical and Electronic Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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