NDLI: Localized electrical nerve blocking

Content Provider	IEEE Xplore Digital Library
Author	Williamson, R.P. Andrews, B.J.
Copyright Year	1964
Abstract	Localized electrical nerve blocking was investigated in computer simulation and in vivo trials for sinusoidal frequencies between 5 and 20 kHz. Computer simulations indicated that a localized transmission block of the axons could occur in each of the axon models. An approximation of nerve stimulation was derived from individual axon simulations conducted over axon diameters of 5-15 /spl mu/m and electrode to axon distances of 0.25 to 2.0 mm. Examination of the membrane voltage and ionic gate potentials indicated that the block could be attributed to an elevated membrane voltage. The elevated membrane voltage could prevent conduction of action potentials through the region of the sinusoidal currents. At lower amplitudes, the sinusoidal current could stimulate the axon and generate a continuous series of action potentials. In vivo trials demonstrated that the sinusoidal frequencies of greater than 10 kHz would cause a localized block in rats. Sinusoidal frequencies below 5 kHz would lead to a reduction in muscle force that appeared to be caused by depletion of transmitter at the neuromuscular junction. As indicated by the computer models of rat nerves, the endplate depletion block occurred at a lower frequency (below 5 kHz) than the block (above 10 kHz). A partial block of the axon was demonstrated, suggesting that sinusoidal currents could be used to provide selective stimulation if they are combined with distal electrical stimulation.
Sponsorship	IEEE Engineering in Medicine and Biology Society
Page Count	9
File Size	2195316
Starting Page	362
Ending Page	370
File Format	PDF
ISSN	00189294
Volume Number	52
Issue Number	3
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-03-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Nerve fibers Frequency Biomembranes Voltage Computer simulation In vivo Computational modeling Electrodes Rats Muscles in vivo trials Axon stimulation computer modeling electrical nerve blocking
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Mechanism of Nerve Conduction Block Induced by High-Frequency Biphasic Electrical Currents

The Role of Slow Potassium Current in Nerve Conduction Block Induced by High-Frequency Biphasic Electrical Current

Simulation analysis of conduction block in myelinated axons induced by high-frequency biphasic rectangular pulses

Analysis of a Model for Excitation of Myelinated Nerve

Modulation of Axonal Excitability by High-Frequency Biphasic Electrical Current

Simulation analysis of conduction block in unmyelinated axons induced by high-frequency biphasic electrical currents

Analysis of models for extracellular fiber stimulation

Current Distance Relations for Fiber Stimulation With Pointsources

Modeling axon membranes for functional electrical stimulation

Localized electrical nerve blocking

Similar Documents

Mechanism of Nerve Conduction Block Induced by High-Frequency Biphasic Electrical Currents

The Role of Slow Potassium Current in Nerve Conduction Block Induced by High-Frequency Biphasic Electrical Current

Simulation analysis of conduction block in myelinated axons induced by high-frequency biphasic rectangular pulses

Analysis of a Model for Excitation of Myelinated Nerve

Modulation of Axonal Excitability by High-Frequency Biphasic Electrical Current

Simulation analysis of conduction block in unmyelinated axons induced by high-frequency biphasic electrical currents

Analysis of models for extracellular fiber stimulation

Current Distance Relations for Fiber Stimulation With Pointsources

Modeling axon membranes for functional electrical stimulation

Localized electrical nerve blocking