NDLI: A Quantitative Model for the Ventricular Response During Atrial Fibrillation

Content Provider	IEEE Xplore Digital Library
Author	Cohen, Richard J. Berger, Ronald D. Dushane, Theodore E.
Copyright Year	1964
Abstract	We review the principal statistical properties of the RR interval sequence during atrial fibrillation. A simple quantitative electrophysiologic model is presented which successfully accounts for these statistical features. In this model the atrioventricular junction (AVJ) is treated as a single cell equivalent characterized by a refractory period and spontaneous rate of phase 4 depolarization. The atria are presumed to bombard the AVJ with impulses that arrive randomly in time; each impulse induces a partial depolarization of the AVJ equivalent cell. We show that other models for the ventricular response during atrial fibrillation (e. g., concealed conduction models) do not adequately account for the salient statistical features of the RR interval sequence. The present model may be utilized to characterize a sequence of RR intervals recorded from a given individual in terms of the numerical magnitudes of the model's four parameters: the mean rate at which atrial impulses bombard the AVJ, the relative amplitude of the impulses, the relative rate of spontaneous phase 4 depolarization of the AVJ equivalent cell, and the refractory period of the AVJ equivalent cell. Such a characterization may be useful in studying mechanisms of drug action and interaction, as well as potentially offering a quantitative means for optimizing pharmacologic manangement of chronic atrial fibrillation.
Sponsorship	IEEE Engineering in Medicine and Biology Society
Page Count	13
File Size	3936336
Starting Page	769
Ending Page	781
File Format	PDF
ISSN	00189294
Volume Number	BME-30
Issue Number	12
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1983-12-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Atrial fibrillation Fluctuations Predictive models Biomedical engineering Hospitals Rhythm Drugs Statistical analysis Biomedical measurements
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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