NDLI: A technique for measurement of the extent of spatial organization of atrial activation during atrial fibrillation in the intact human heart

Content Provider	IEEE Xplore Digital Library
Author	Botteron, G.W. Smith, J.M.
Copyright Year	1964
Abstract	Atrial fibrillation (AF) is a common clinical problem, associated with considerable morbidity and motility, for which effective management strategies have yet to be devised. The absence of objective measures to guide selection of antiarrhythmic drug therapy for maintenance of sinus rhythm leaves only clinical endpoints (either beneficial or detrimental) for assessment of drug action, with occasional catastrophic consequences. As part of an attempt to provide an objective framework for the assessment of antiarrhythmic drug action on the electrophysiologic determinants of atrial fibrillation, the authors have developed a measure of the spatial organization of atrial activation processes during atrial fibrillation. By recording activation sequences at multiple equally spaced locations on the endocardial surface of the atrial during atrial fibrillation in humans and determining the degree of correlation between these activation sequences as a function of distance, the authors have been able to construct spatial correlation functions for atrial activation. They have found that atrial activation remains well-correlated, independent of distance during normal sinus rhythm and atrial flutter. During atrial fibrillation, correlation decays monotonically with distance and the space-constant for this decay may be used to describe the relative spatial organization of atrial fibrillation. The authors provide examples of the impact of antiarrhythmic agents on the space-constant and suggest that assessment of the relative spatial organization of atrial activation using this methodology may potentially provide an objective framework to guide therapy in patients with AF.<>
Sponsorship	IEEE Engineering in Medicine and Biology Society
Page Count	8
File Size	911053
Starting Page	579
Ending Page	586
File Format	PDF
ISSN	00189294
Volume Number	42
Issue Number	6
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1995-06-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Atrial fibrillation Drugs Medical treatment Humans Rhythm Cardiology Heart Embolization Hypertension Cardiac disease
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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