NDLI: A Localized Surface Plasmon Resonance-Based Portable Instrument for Quick On-Site Biomolecular Detection

Content Provider	IEEE Xplore Digital Library
Author	Rampazzi, S. Danese, G. Leporati, F. Marabelli, F.
Copyright Year	1963
Abstract	In recent years, several approaches have been developed to carry out biosensors based on localized surface plasmon resonance (LSPR). However, the high costs of nanostructure fabrication and the absence of autonomous portable devices strongly limit the extensive use of LSPR biosensors outside the research laboratories. We designed, implemented, and tested a novel low cost multiparametric stand-alone LSPR imaging instrument for biosensing applications. This compact device (15 × 6 × 17 cm³ size and <;500-g weight) consists of a nanohole array biochip integrated with a microfluidic layer and a processing system. An optical apparatus focuses a light beam from an IR LED source and a digital image sensor captures the reflected light from the biochip surface. The signals are processed by the embedded ARM processor and shown on a touchscreen display by a user-friendly application, without the need for other external computational devices. Moreover, we propose an extremely simple analytical method to reduce the image noise without any sophisticated temperature control or external luminosity change compensation. The device sensitivity of $6 \times 10^{\mathrm {-5}}$ refractive index unit was measured using glycerol solutions with different concentrations. We demonstrated the efficiency of our system in biomolecular detection by monitoring the Ab-PTX3 antibody in a test that showed the instrument's potentialities in the detection of antibodies. These results confirmed the potential usefulness of the proposed system in several biomedical applications such as medical diagnostic procedures, immunoassays, or fast in loco preliminary analyses without the aid of specialized laboratory or trained personnel.
Sponsorship	IEEE Instrumentation and Measurement Society Bureau international des poids et mesures IEEE International Bureau of Weights and Measures (BIPM) URSI NBS Agency Ind. Sci. & Technol., Min. Int. Trade & Ind. Sci. Council Japan International Union of Pure and Applied Physics (IUPAP) NIST NRCC National Conference of Standards Laboratories (NCSL) Allen Osborne Associates Andeen-Hagerling, Inc. Ballantine Lab. Inc. Clarke-Hess Communications Research Corp. Fluke Corporation Guildline Instruments Hewlett-Packard Co. Julie Res. Lab. Inc. Keithley Instruments, Inc. Measurements International Ltd. Canada QuadTech Inc. Quantum Design Inc. Rotek Instrum. Corp. Tegam Inc. Tektronix Inc
Starting Page	317
Ending Page	327
Page Count	11
File Size	1754807
File Format	PDF
ISSN	00189456
Volume Number	65
Issue Number	2
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2016-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Biosensors Sensitivity Nanobioscience Metals Biomedical optical imaging Optical refraction Optical sensors portable embedded systems. ARM processors bioassay measurements biomedical instrumentations biosensors digital signal processing (DSP) localized surface plasmon resonance (LSPR) optic imaging portable embedded systems
Content Type	Text
Resource Type	Article
Subject	Instrumentation Electrical and Electronic Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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