NDLI: Development of Red Blood Cell–Photon Simulator for Optical Propagation Analysis in Blood using Monte Carlo Method

Content Provider	IEEE Xplore Digital Library
Author	Oshima, S. Sankai, Y.
Copyright Year	1997
Abstract	We have developed a “red blood cell (RBC)-photon simulator” to reveal optical propagation in prethrombus blood for various levels of RBC density and aggregation. The simulator investigates optical propagation in the prethrombus blood and will be applied to detect it noninvasively for thrombosis prevention in an earlier stage. In our simulator, Lambert-Beer's law is employed to simulate the absorption of RBCs with hemoglobin, while the Monte Carlo method is applied to simulate scattering through iterative calculations. One advantage of our simulator is that concentrations and distributions of RBCs can be arbitrarily chosen to exhibit the prethrombus, while conventional models cannot. Using the simulator, we found that various levels of RBC density and aggregation have different effects on the optical propagation of near-infrared response light in blood. The same different effects were acquired in in vitro experiments with 12 bovine blood samples, which were performed to evaluate the simulator. We measured RBC density using the clinical hematocrit index and RBC aggregation using activated whole blood clotting time. The experimental results correspond to the simulator results well. Therefore, we could show that our simulator exhibits the correct optical propagation for prethrombus blood and is applicable for the prethrombus detection using multiple detectors.
Sponsorship	IEEE Engineering in Medicine and Biology Society IEEE Computer Society
Page Count	8
File Size	778950
Starting Page	356
Ending Page	363
File Format	PDF
ISSN	10897771
Volume Number	15
Issue Number	3
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-05-01
Publisher Place	U.S.A.
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Blood Optical propagation Photonics Optical scattering Stimulated emission Biomedical optical imaging optical propagation analysis Biomedical monitoring blood information detections Monte Carlo simulation near-infrared detections (NIR)
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering Computer Science Applications Biotechnology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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