NDLI: A Contamination Aware Droplet Routing Algorithm for the Synthesis of Digital Microfluidic Biochips

Content Provider	IEEE Xplore Digital Library
Author	Tsung-Wei Huang Chun-Hsien Lin Tsung-Yi Ho
Copyright Year	1982
Abstract	Recent advances of digital microfluidic biochips (DMFBs) have revolutionized the traditional laboratory procedures. By providing the droplet-based system, DMFB can perform real-time biological analysis and safety-critical biomedical applications. However, different droplets being transported and manipulated on the DMFB may introduce the contamination problem caused by liquid residue between different biomolecules. To overcome this problem, a wash droplet is introduced to clean the contaminations on the surface of the microfluidic array. However, current scheduling of wash droplet does not restrict the extra used cells and execution time of bioassay, thereby degrading the reliability and fault-tolerance significantly. In this paper, we propose a contamination aware droplet routing algorithm for DMFBs. To reduce the routing complexity and the used cells, we first construct preferred routing tracks by analyzing the global moving vector of droplets to guide the droplet routing. To cope with contaminations within one subproblem, we first apply a k -shortest path routing technique to minimize the contaminated spots. Then, to take advantage of multiple wash droplets, we adopt a minimum cost circulation (MCC) algorithm for optimal wash-droplet routing to simultaneously minimize used cells and the cleaning time. Since the droplet routing problem consists of several subproblems, a look-ahead prediction technique is further used to determine the contaminations between successive subproblems. After that, we can simultaneously clean both contaminations within one subproblem and those between successive subproblems by using the MCC-based algorithm to reduce the execution time and the used cells significantly. Based on four widely used bioassays, our algorithm reduces the used cells and the execution time significantly compared with the state-of-the-art algorithm.
Sponsorship	IEEE Council on Electronic Design Automation IEEE Circuits and Systems Society
Starting Page	1682
Ending Page	1695
Page Count	14
File Size	1432844
File Format	PDF
ISSN	02780070
Volume Number	29
Issue Number	11
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-11-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Routing Contamination Arrays Timing Heuristic algorithms Algorithm design and analysis Complexity theory routing Biochips contaminations dynamic programming minimum cost circulation (MCC)
Content Type	Text
Resource Type	Article
Subject	Computer Graphics and Computer-Aided Design Electrical and Electronic Engineering Software

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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