NDLI: China Physiome Project: A Comprehensive Framework for Anatomical and Physiological Databases From the China Digital Human and the Visible Rat

Content Provider	IEEE Xplore Digital Library
Author	Dao Han Qian Liu Qingming Luo
Copyright Year	1963
Abstract	The connection study between biological structure and function, as well as between anatomical data and mechanical or physiological models, has been of increasing significance with the rapid advancement in experimental physiology and computational physiology. The China Physiome Project (CPP) is dedicated in optimization of the connection exploration based on standardization and integration of the structural datasets and their derivatives of cryosectional images with various standards, collaboration mechanisms, and online services. The CPP framework hereby incorporates the three-dimensional anatomical models of human and rat anatomy, the finite-element models of whole-body human skeleton, and the multiparticle radiological dosimetry data of both the human and rat computational phantoms. The ontology of CPP was defined using MeSH and, with its all standardized models description implemented by M3L, a multiscale modeling language based on XML. Provided services based on Wiki concept include collaboration research, modeling version control, data sharing, online analysis of M3L documents. As a sample case, a multiscale model for human heart modeling, in which familiar hypertrophic cardiomyopathy was studied according to the structure-function relations from genetic level to organ level, is integrated into the framework and given for demonstration of the functionality of multiscale physiological modeling based on CPP.
Sponsorship	IEEE Publication
Starting Page	1969
Ending Page	1976
Page Count	8
File Size	924252
File Format	PDF
ISSN	00189219
Volume Number	97
Issue Number	12
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-12-01
Publisher Place	U.S.A.
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Databases Humans Physiology Online Communities/Technical Collaboration Biological system modeling Biology computing Standardization Anatomy Finite element methods Skeleton Wiki China Digital Human database markup language Physiome Project Visible Rat phantom
Content Type	Text
Resource Type	Article
Subject	Computer Science Electrical and Electronic Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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