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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Watson, C.C. |
| Copyright Year | 1963 |
| Abstract | We describe a new, noise-adaptive, quasi-linear image reconstruction algorithm for positron emission tomography that seeks to equalize the signal-to-noise ratio (SNR) across an image by applying spatially varying smoothing. It is based on the fact that for linear reconstruction algorithms such as filtered back-projection (FBP), operating on uncorrelated Poisson distributed data, it is possible to directly compute the corresponding noise variance image, and thus the SNR, at all points, for any smoothing kernel (or filter function). Increased smoothing generally results in higher SNR. Therefore, by varying the amount of smoothing locally, one can tune the image to achieve a target SNR at most points. The resulting image appears to share some of the advantages of maximum likelihood reconstruction (e.g., improved hot spot contrast versus noise trade-off) while retaining the quantitative advantages of FBP (biased only by the known smoothing kernel). Examples for clinical time-of-flight (TOF) and non-TOF reconstructions are shown. |
| Sponsorship | IEEE Nuclear and Plasma Sciences Society Computer Applications in Nuclear and Plasma Sciences (CANPS) Lawrence Berkeley Lab. Lawrence Livermore Nat. Lab. APS College of William and Mary Continuous Electron Beam Accelerator Facility NASA Defence Nuclear Agency Sandia National Laboratories Jet Propulsion Laboratory Brookhaven Nat. Lab. Lawrence Livermore Nat. Lab IEEE/NPPS Radiat. Effects Committee Defence Nuclear Agency/DoD Sandia National Laboratories/DOE Jet Propulsion Laboratory/NASA Phillips Lab./DoD |
| Starting Page | 108 |
| Ending Page | 115 |
| Page Count | 8 |
| File Size | 1908186 |
| File Format | |
| ISSN | 00189499 |
| Volume Number | 56 |
| Issue Number | 1 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2009-02-01 |
| Publisher Place | U.S.A. |
| Access Restriction | One Nation One Subscription (ONOS) |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Signal to noise ratio Positron emission tomography Smoothing methods Image reconstruction Kernel Nonlinear filters Reconstruction algorithms Maximum likelihood estimation Iterative algorithms Pixel SNR FBP image reconstruction PET |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nuclear and High Energy Physics Electrical and Electronic Engineering Nuclear Energy and Engineering |
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