NDLI: Integrated Circuit Biosensors Using Living Whole-Cell Bioreporters

Content Provider	IEEE Xplore Digital Library
Author	Islam, S.K. Vijayaraghavan, R. Mo Zhang Ripp, S. Caylor, S.D. Weathers, B. Moser, S. Terry, S. Blalock, B.J. Sayler, G.S.
Copyright Year	2004
Abstract	A low-power CMOS bioluminescent bioreporter integrated circuit (BBIC) is designed and fabricated for use in electronic/biological chemical sensing. The bioreporters are placed on a CMOS integrated circuit (IC) that detects bioluminescence, performs signal processing and produces a digital output pulse with a frequency that is proportional to the concentration of the target substance. The digital output pulse that contains the sensor information can then be transmitted to a remote location either wirelessly or via a data cable. The basic building blocks of the integrated circuit are the microluminometer and the transmitter. The microluminometer includes an integrated photodetector and a signal processor and is housed in a rugged inexpensive package that can be used in many remote applications in hazardous environmental monitoring. The total power consumption of the entire signal processing circuitry including the photodiodes is 3 mW from a 3.3-V power supply. This is lowered by a factor of 3 when compared to previous versions of the BBIC. In addition, it also integrates all features of detection, processing and data transmission into one small element. The bioreporter typically contains the luxCDABE reporter genes. The close proximity of the bioreporter and the sensing element eliminates the need for complex instrumentation to channel light from the bioreporters to the microluminometer. This paper presents an integrated CMOS microluminometer realized in 0.35-mum CMOS process and optimized for the detection of low-level bioluminescence as part of the BBIC. A flow-through test system was designed to expose the BBIC system composed of the microluminometer and the bioreporter Pseudomonas fluorescens 5RL to salicylate for determination of analytical benchmark data. The results obtained from the experiment are currently being used to study enclosures and micro-environment configurations for field-deployable BBICs for environmental monitoring
Sponsorship	IEEE Circuits and Systems Society
Starting Page	89
Ending Page	98
Page Count	10
File Size	2288260
File Format	PDF
ISSN	15498328
Volume Number	54
Issue Number	1
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Biosensors Bioluminescence CMOS integrated circuits Biomedical signal processing CMOS process Chemicals CMOS digital integrated circuits Digital signal processing Pulse circuits Frequency whole-cell biosensors Bioluminescent bioreporter integrated circuit (BBIC) bioreporters CMOS photodetectors microluminometer
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering Hardware and Architecture

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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