NDLI: Iodine 125 Imaging in Mice Using NaI(Tl)/Flat Panel PMT Integral Assembly

Content Provider	IEEE Xplore Digital Library
Author	Cinti, M.N. Majewski, S. Williams, M.B. Bachmann, C. Cominelli, F. Kundu, B.K. Stolin, A. Popov, V. Welch, B.L. De Vincentis, G. Bennati, P. Betti, M. Ridolfi, S. Pani, R.
Copyright Year	1963
Abstract	Radiolabeled agents that bind to specific receptors have shown great promise in diagnosing and characterizing tumor cell biology. In vivo imaging of gene transcription and protein expression represents an other area of interest. The radioisotope I is commercially available as a label for molecular probes and utilized by researchers in small animal studies. We propose an advanced imaging detector based on planar NaI(T1) integral assembly with a Hamamatsu Flat Panel Photomultiplier (MA-PMT) representing one of the best trade-offs between spatial resolution and detection efficiency. We characterized the imaging performances of this planar detector, in comparison with a gamma camera based on a pixellated scintillator. We also tested the in-vivo image capability by acquiring images of mice as a part of a study of inflammatory bowel disease (IBD). In this study, four 25g mice with an IBD-like phenotype (SAMP1/YitFc) were injected with 375, 125, 60 and 30 muCi of I-labelled antibody against mucosal vascular addressin cell adhesion molecule (MAdCAM-1), which is up-regulated in the presence of inflammation. Two mice without bowel inflammation were injected with 150 and 60 muCi of the labeled anti-MAdCAM-1 antibody as controls. To better evaluate the performances of the integral assembly detector, we also acquired mice images with a dual modality (X and Gamma Ray) camera dedicated for small animal imaging. The results coming from this new detector are considerable: images of SAMP1/YitFc injected with 30 muCi activity show inflammation throughout the intestinal tract, with the disease very well defined at two hours post-injection.
Sponsorship	IEEE Nuclear and Plasma Sciences Society Computer Applications in Nuclear and Plasma Sciences (CANPS) Lawrence Berkeley Lab. Lawrence Livermore Nat. Lab. APS College of William and Mary Continuous Electron Beam Accelerator Facility NASA Defence Nuclear Agency Sandia National Laboratories Jet Propulsion Laboratory Brookhaven Nat. Lab. Lawrence Livermore Nat. Lab IEEE/NPPS Radiat. Effects Committee Defence Nuclear Agency/DoD Sandia National Laboratories/DOE Jet Propulsion Laboratory/NASA Phillips Lab./DoD
Starting Page	461
Ending Page	468
Page Count	8
File Size	2672612
File Format	PDF
ISSN	00189499
Volume Number	54
Issue Number	3
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-06-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Mice Assembly Optical imaging Animals Gamma ray detection Gamma ray detectors Cameras Diseases Tumors Cells (biology) scintillation detectors Biomedical nuclear imaging photomultipliers
Content Type	Text
Resource Type	Article
Subject	Nuclear and High Energy Physics Electrical and Electronic Engineering Nuclear Energy and Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Factors Affecting Hamamatsu H8500 Flat Panel PMT Calibration for Gamma Ray Imaging

Scintillation Characteristics of Thin NaI(Tl) and CsI (Tl) Layers Fabricated by Vacuum Deposition

CsI(Tl) Micro-Pixel Scintillation Array for Ultra-high Resolution Gamma-ray Imaging

A new compact position-sensitive PMT for scintillation detectors

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A compact gamma camera for biological imaging

Imaging Efficiency of Ge and NaI(Tl) Gamma-Ray Detectors

Investigation of a continuous crystal PSAPD-based gamma camera

More on the scintillation response of NaI(Tl)

Iodine 125 Imaging in Mice Using NaI(Tl)/Flat Panel PMT Integral Assembly

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Factors Affecting Hamamatsu H8500 Flat Panel PMT Calibration for Gamma Ray Imaging

Scintillation Characteristics of Thin NaI(Tl) and CsI (Tl) Layers Fabricated by Vacuum Deposition

CsI(Tl) Micro-Pixel Scintillation Array for Ultra-high Resolution Gamma-ray Imaging

A new compact position-sensitive PMT for scintillation detectors

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Imaging Efficiency of Ge and NaI(Tl) Gamma-Ray Detectors

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More on the scintillation response of NaI(Tl)

Iodine 125 Imaging in Mice Using NaI(Tl)/Flat Panel PMT Integral Assembly