NDLI: Transient Block of Receptor May Be a Mechanism Controlling Unidirectional Propagation of Signaling

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Transient Block of Receptor May Be a Mechanism Controlling Unidirectional Propagation of Signaling

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Issue 2

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Year : 2005 Volume : 4

Year : 2004 Volume : 3

Year : 2003 Volume : 2

Year : 2002 Volume : 99

Transient Block of Receptor May Be a Mechanism Controlling Unidirectional Propagation of Signaling

Content Provider	IEEE Xplore Digital Library
Author	Hao Zhu Dhar, P.K.
Copyright Year	2002
Abstract	In tissue development, juxtacrine signaling often propagates across cells, carrying and delivering temporal and spatial information for cells to make correct patterning. Observed complex and accurate tissue patterning indicates that signaling propagation via ligand-receptor interactions is precisely controlled. It is important and interesting to reveal the possible control mechanisms. The directionality of signaling in cells, which is a common issue for all intercellular signaling pathways, is a critical aspect. To understand the propagation of Notch signaling in presomitic mesoderm cells in the mouse, a novel method is used to build a multicellular model to simulate Notch signaling. Simulation reveals that the transient block of Notch by Notch induced Lfng and the delayed removal of the block by another Notch induced protein Hes7 may explain the observed unidirectional propagation of Notch signaling in these cells. Both mutation in and overexpression of lfng cause the same signaling profile in the tissue, due to the inappropriate timing of Notch signaling block by Lfng. The reverse Notch/Delta signaling quickly develops into reciprocating signaling among cells, causing irregular expression of cyclic genes. Irregular Notch signaling in cells would change their response to the positional information provided by the Fgf8 gradient, resulting in disordered and irregular somite segmentation. As Notch signaling is highly conserved, we hypothesize that the mechanism of controlling unidirectional propagation of signaling in cells by transient receptor block may exist in other tissues and in other vertebrates. Our simulation results also suggest that segmentation clock and unidirectional propagation may be inherently coupled in Notch signaling
Sponsorship	IEEE Engineering in Medicine and Biology Society IEEE Systems, Man, and Cybernetics Society IEEE Nanotechnology Council IEEE Computational Intelligence Society IEEE Robotics and Automation Society IEEE Computer Society
Page Count	11
File Size	512093
Starting Page	193
Ending Page	203
File Format	PDF
ISSN	15361241
Volume Number	5
Issue Number	3
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-09-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Signal processing Bioinformatics Mice Computational modeling Propagation delay Proteins Genetic mutations Timing Automatic control Biological system modeling somite segmentation Cellular automata delta notch propagation signaling
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Medicine Bioengineering Electrical and Electronic Engineering Biomedical Engineering Computer Science Applications Biotechnology Pharmaceutical Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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