NDLI: <italic>In Vivo</italic> Irreversible Electroporation Kidney Ablation: Experimentally Correlated Numerical Models

Content Provider	IEEE Xplore Digital Library
Author	Neal, R.E. Garcia, P.A. Kavnoudias, H. Rosenfeldt, F. Mclean, C.A. Earl, V. Bergman, J. Davalos, R.V. Thomson, K.R.
Copyright Year	1964
Abstract	Irreversible electroporation (IRE) ablation uses brief electric pulses to kill a volume of tissue without damaging the structures contraindicated for surgical resection or thermal ablation, including blood vessels and ureters. IRE offers a targeted nephron-sparing approach for treating kidney tumors, but the relevant organ-specific electrical properties and cellular susceptibility to IRE electric pulses remain to be characterized. Here, a pulse protocol of 100 electric pulses, each 100 μs long, is delivered at 1 pulse/s to canine kidneys at three different voltage-to-distance ratios while measuring intrapulse current, completed 6 h before humane euthanasia. Numerical models were correlated with lesions and electrical measurements to determine electrical conductivity behavior and lethal electric field threshold. Three methods for modeling tissue response to the pulses were investigated (static, linear dynamic, and asymmetrical sigmoid dynamic), where the asymmetrical sigmoid dynamic conductivity function most accurately and precisely matched lesion dimensions, with a lethal electric field threshold of 575 ± 67 V/cm for the protocols used. The linear dynamic model also attains accurate predictions with a simpler function. These findings can aid renal IRE treatment planning under varying electrode geometries and pulse strengths. Histology showed a wholly necrotic core lesion at the highest electric fields, surrounded by a transitional perimeter of differential tissue viability dependent on renal structure.
Sponsorship	IEEE Engineering in Medicine and Biology Society
Starting Page	561
Ending Page	569
Page Count	9
File Size	3534517
File Format	PDF
ISSN	00189294
Volume Number	62
Issue Number	2
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-01-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Conductivity Electric fields Electrodes Lesions Kidney Numerical models Protocols Translational Targeted Cancer Therapy Bioimpedance Dynamic conductivity IRE Nonthermal Focal Tumor Ablation translational targeted cancer therapy dynamic conductivity nonthermal focal tumor ablation
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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