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Mutations in the rpoB Gene of Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates from India
| Content Provider | ICMR - National Institute of Research in Tuberculosis (NIRT) |
|---|---|
| Author | Narayanan, Sujatha Mani, Cheruvu Narayanan, P. R. Selvakumar, N. |
| Abstract | Mutations in the 81-bp rifampin resistance-determining region (RRDR) of the rpoB gene were analyzed by DNA sequencing of 50 Mycobacterium tuberculosis clinical isolates (44 resistant and 6 sensitive) from various parts of India. Fifty-three mutations of 18 different kinds, 17 point mutations and one deletion, were observed in 43 of 44 resistant isolates. Three novel mutations and three new alleles within the RRDR, along with two novel mutations outside the RRDR, are reported in this study. |
| Ending Page | 2990 |
| Starting Page | 2987 |
| File Format | |
| ISSN | 00951137 |
| e-ISSN | 1098660X |
| Issue Number | 8 |
| Volume Number | 39 |
| Language | English |
| Publisher | Journal of Clinical Microbiology |
| Publisher Date | 2001-01-01 |
| Access Restriction | Open |
| Subject Keyword | Public Health RpoB gene Rifampin (RIF) Resistance Rifampinresistance-determining region (RRDR) Healthcare DNA Sequencing Medical Research |
| Content Type | Text |
| Resource Type | Article |
| Subject | Microbiology (medical) |
