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Real-time, single-step bioassay using nanoplasmonic resonator with ultra-high sensitivity
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Copyright Year | 2014 |
| Description | A nanoplasmonic resonator (NPR) comprising a metallic nanodisk with alternating shielding layer(s), having a tagged biomolecule conjugated or tethered to the surface of the nanoplasmonic resonator for highly sensitive measurement of enzymatic activity. NPRs enhance Raman signals in a highly reproducible manner, enabling fast detection of protease and enzyme activity, such as Prostate Specific Antigen (paPSA), in real-time, at picomolar sensitivity levels. Experiments on extracellular fluid (ECF) from paPSA-positive cells demonstrate specific detection in a complex bio-fluid background in real-time single-step detection in very small sample volumes. |
| File Size | 2594609 |
| Page Count | 25 |
| File Format | |
| Alternate Webpage(s) | http://archive.org/details/NASA_NTRS_Archive_20150003241 |
| Archival Resource Key | ark:/13960/t0wq4zv3v |
| Language | English |
| Publisher Date | 2014-04-01 |
| Access Restriction | Open |
| Subject Keyword | Prostate Gland Patents Antigens Bioassay Protease Inventions Shielding Conjugation Resonators Real Time Operation Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
| Resource Type | Patent |
