NDLI: Space exploration: a risk for neural stem cells

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Space exploration: a risk for neural stem cells

Content Provider	NASA Technical Reports Server (NTRS)
Author	Chamberland, Dennis W. Vazquez, Marcelo E. Steindler, Dennis A. Switzer, Robert C. Levine, Howard G. Enikolopov, Grigori Nick, Harry Encinas, Juan M. Scarpa, Philip J.
Copyright Year	2006
Description	During spaceflights beyond low Earth orbit, astronauts are exposed to potentially carcinogenic and tissue damaging galactic cosmic rays, solar proton events, and secondary radiation that includes neutrons and recoil nuclei produced by nuclear reactions in spacecraft walls or in tissue (1). Such radiation risk may present a significant health risk for human exploration of the moon and Mars. Emerging evidence that generation of new neurons in the adult brain may be essential for learning, memory, and mood (2) and that radiation is deleterious to neurogenesis (3-5) underscores a previously unappreciated possible risk to the cognitive functions and emotional stability of astronauts exposed to radiation in space. Here we use a novel reporter mouse line to identify at-risk populations of stem and progenitor cells in the brain and find, unexpectedly, that quiescent stem-like cells (rather than their rapidly dividing progeny) in the hippocampus constitute the most vulnerable cell population. This finding raises concerns about the possible risks facing astronauts on long duration space missions.
File Size	788957
Page Count	12
File Format	PDF
Alternate Webpage(s)	http://archive.org/details/NASA_NTRS_Archive_20130012602
Archival Resource Key	ark:/13960/t0ps2rk1w
Language	English
Publisher Date	2006-01-01
Access Restriction	Open
Subject Keyword	Aerospace Medicine Brain Cells Biology Space Missions Low Earth Orbits Health Galactic Cosmic Rays Stem Cells Risk Astronauts Extraterrestrial Radiation Space Flight Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science
Content Type	Text
Resource Type	Article

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