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Methods of dna methylation detection
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Copyright Year | 2010 |
| Description | The present invention provides for methods of DNA methylation detection. The present invention provides for methods of generating and detecting specific electronic signals that report the methylation status of targeted DNA molecules in biological samples.Two methods are described, direct and indirect detection of methylated DNA molecules in a nano transistor based device. In the direct detection, methylated target DNA molecules are captured on the sensing surface resulting in changes in the electrical properties of a nano transistor. These changes generate detectable electronic signals. In the indirect detection, antibody-DNA conjugates are used to identify methylated DNA molecules. RNA signal molecules are generated through an in vitro transcription process. These RNA molecules are captured on the sensing surface change the electrical properties of nano transistor thereby generating detectable electronic signals. |
| File Size | 808388 |
| Page Count | 11 |
| File Format | |
| Alternate Webpage(s) | http://archive.org/details/NASA_NTRS_Archive_20100040706 |
| Archival Resource Key | ark:/13960/t5fc02362 |
| Language | English |
| Publisher Date | 2010-09-14 |
| Access Restriction | Open |
| Subject Keyword | Patents Electrical Properties Deoxyribonucleic Acid Inventions Methyl Compounds Methylation Detection Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
| Resource Type | Patent |
