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Stress-induced subclinical reactivation of varicella zoster virus in astronauts
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Author | Gilden, Donald H. Zerbe, Gary Pierson, Duane L. Forghani, Bagher Mehta, Satish K. Cohrs, Randall J. |
| Copyright Year | 2003 |
| Description | After primary infection, varicella-zoster virus (VZV) becomes latent in ganglia. VZV reactivation occurs primarily in elderly individuals, organ transplant recipients, and patients with cancer and AIDS, correlating with a specific decline in cell-mediated immunity to VZV. VZV can also reactivate after surgical stress. To determine whether VZV can also reactivate after acute non-surgical stress, we examined total DNA extracted from 312 saliva samples of eight astronauts before, during and after space flight for VZV DNA by PCR: 112 samples were obtained 234 to 265 days before flight, 84 samples on days 2 through 13 of space flight, and 116 samples on days 1 through 15 after flight. Before space flight only one of the 112 saliva samples from a single astronaut was positive for VZV DNA. In contrast, during and after space flight, 61 of 200 (30%) saliva samples were positive in all 8 astronauts. No VZV DNA was detected in any of 88 saliva samples from 10 healthy control subjects. These data indicate that VZV can reactivate subclinically in healthy individuals after acute stress. |
| File Size | 5395933 |
| Page Count | 12 |
| File Format | |
| Alternate Webpage(s) | http://archive.org/details/NASA_NTRS_Archive_20100035161 |
| Archival Resource Key | ark:/13960/t1pg6n242 |
| Language | English |
| Publisher Date | 2003-01-01 |
| Access Restriction | Open |
| Subject Keyword | Aerospace Medicine Infectious Diseases Deoxyribonucleic Acid Organs Viral Diseases Viruses Astronauts Patients Saliva Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
| Resource Type | Article |
