NDLI: Increased ebv shedding in astronaut saliva during spaceflight

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Increased ebv shedding in astronaut saliva during spaceflight

Content Provider	NASA Technical Reports Server (NTRS)
Author	Mehta, S. K. Lugg, D. J. Phillips, T. Stowe, R. P. Pierson, D. L.
Copyright Year	2003
Description	Shedding of Epstein-Barr virus (EBV) by astronauts before, during, and after space shuttle missions was quantified. Of 1398 saliva specimens from 32 astronauts, 314 (23%) were positive for EBV DNA by PCR analysis. Of the saliva specimens collected before flight, 29% were positive for EBV DNA and of those collected during or after flight, 16% were EBV-positive. The number of EBV DNA copies from samples taken during the flight was 417+/-31, significantly higher (P < 0.05) than the number of copies from the preflight (40+/-1.7) and postflight (44+/-5) phases. Eighteen control subjects shed EBV DNA with a frequency of 3.7% and a copy number of 40+/-2 per ml saliva. Ten days before flight and on landing day, antibody titers to EBV viral capsid antigen (VCA) were significantly (P < 0.05) higher than baseline levels. On landing day, urinary level of cortiso1 and catecholamines, and plasma levels of substance P and other neuropeptides, were increased over their preflight value. Results suggested that stress associated with spaceflight decreases cellular immunity and thereby leads to increased viral reactivation.
File Size	8100118
Page Count	25
File Format	PDF
Alternate Webpage(s)	http://archive.org/details/NASA_NTRS_Archive_20110000846
Archival Resource Key	ark:/13960/t3907316n
Language	English
Publisher Date	2003-01-01
Access Restriction	Open
Subject Keyword	Aerospace Medicine Antigens Peptides Plasmas Physics Deoxyribonucleic Acid Space Shuttle Missions Antibodies Viruses Astronauts Space Flight Catecholamine Saliva Urology Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science
Content Type	Text
Resource Type	Article

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