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Nonenzymatic catalytic signal amplification for nucleic acid hybridization assays
| Content Provider | NASA Technical Reports Server (NTRS) |
|---|---|
| Copyright Year | 2006 |
| Description | Devices, methods, and kits for amplifying the signal from hybridization reactions between nucleic acid probes and their cognate targets are presented. The devices provide partially-duplexed, immobilized probe complexes, spatially separate from and separately addressable from immobilized docking strands. Cognate target acts catalytically to transfer probe from the site of probe complex immobilization to the site of immobilized docking strand, generating a detectable signal. The methods and kits of the present invention may be used to identify the presence of cognate target in a fluid sample. |
| File Size | 1415347 |
| Page Count | 17 |
| File Format | |
| Alternate Webpage(s) | http://archive.org/details/NASA_NTRS_Archive_20080008705 |
| Archival Resource Key | ark:/13960/t08w8cv6x |
| Language | English |
| Publisher Date | 2006-02-28 |
| Access Restriction | Open |
| Subject Keyword | Amplification Patents Targets Nucleic Acids Assaying Kits Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science |
| Content Type | Text |
| Resource Type | Patent |
