NDLI: Skeletal responses to spaceflight

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Skeletal responses to spaceflight

Content Provider	NASA Technical Reports Server (NTRS)
Author	Morey-Holton, Emily Arnaud, Sara B.
Copyright Year	1991
Description	The role of gravity in the determination of bone structure is elucidated by observations in adult humans and juvenile animals during spaceflight. The primary response of bone tissue to microgravity is at the interface of the mineral and matrix in the process of biomineralization. This response is manifested by demineralization or retarded growth in some regions of the skeleton and hypermineralization in others. The most pronounced effects are seen in the heelbone and skull, the most distally located bones relative to the heart. Ground based flight simulation models that focus on changes in bone structure at the molecular, organ, and whole body levels are described and compared to flight results. On Earth, the morphologic and compositional changes in the unloaded bones are very similar to changes during flight; however, the ground based changes appear to be more transient. In addition, a redistribution of bone mineral in gravity-dependent bones occurs both in space and during head down positioning on Earth. Longitudinal data provided considerable information on the influence of endocrine and muscular changes on bone structure after unloading.
File Size	2494514
Page Count	38
File Format	PDF
Alternate Webpage(s)	http://archive.org/details/NASA_NTRS_Archive_19920014181
Archival Resource Key	ark:/13960/t2w42nz7b
Language	English
Publisher Date	1991-12-01
Access Restriction	Open
Subject Keyword	Aerospace Medicine Heart Positioning Physiological Effects Animals Gravitational Effects Bone Demineralization Calcification Bones Skull Space Flight Microgravity Flight Simulation Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science
Content Type	Text
Resource Type	Technical Report

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