NDLI: Genetic toxicity studies of organic chemicals found as contaminants in spacecraft cabin atmospheres

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Genetic toxicity studies of organic chemicals found as contaminants in spacecraft cabin atmospheres

Content Provider	NASA Technical Reports Server (NTRS)
Author	Torres Jr., Joseph
Copyright Year	1987
Description	Astronauts can be exposed during spaceflight to organic chemical contaminants in the spacecraft cabin atmosphere. Toxic exposures may cause lesions in the cellular DNA which are subsequently expressed as sister-chromatid exchanges (SCE). Analysis of SCE is a sensitive short term assay techinque to detect and quantitate exposures to DNA damaging (mutagenic) substances. The increase in SCE incidence over baseline (control) levels is generally proportional to the concentration of the mutagen and to the duration of exposure. The BHK-21 baby hamster kidney cell line was the in vitro test system used. Test organics were added to the culture media for 18 hrs, in concentrations ranging from one to 20 ppm. Acetaldehyde and carbon disulfide were chosen for this study since they have occurred as atmospheric contaminants in many of the STS flights, and have been reported to have toxic and mutagenic effects in various test systems. Glutaraldehyde was chosen because few data are available on the mutagenicity of this common fixative, which is carried on STS flights for use in biological experiments. Acetaldehyde was a very strong inducer of SCE at concentrations of 2 ppm and above. Glutaraldehyde and carbon disulfide failed to induce SCE.
File Size	419446
Page Count	14
File Format	PDF
Alternate Webpage(s)	http://archive.org/details/NASA_NTRS_Archive_19870016464
Archival Resource Key	ark:/13960/t3kx0946m
Language	English
Publisher Date	1987-06-01
Access Restriction	Open
Subject Keyword	Man/system Technology And Life Support Organic Chemistry Genetic Code Bioassay Mutagens Carbon Disulfide Spacecraft Contamination Toxicity Spacecraft Cabin Atmospheres Air Pollution Lesions Chromosomes Acetaldehyde Ntrs Nasa Technical Reports Server (ntrs) Nasa Technical Reports Server Aerodynamics Aircraft Aerospace Engineering Aerospace Aeronautic Space Science
Content Type	Text
Resource Type	Technical Report

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