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Palladium and Copper Catalyzed Sonogashira Decarboxylative Coupling of Aryl Halides and Alkynyl Carboxylic Acids
| Content Provider | Hyper Articles en Ligne (HAL) |
|---|---|
| Author | Chevalier, Yoan Maaliki, Carine Thiery, Emilie Thibonnet, Jérôme |
| Abstract | The Sonogashira cross-coupling reaction is the most useful tool for the formation of the C(sp2) – C(sp) bond and it is used as a key step in total synthesis. This reaction proceeds via palladium catalyzed coupling between aryl halides and terminal alkynes in the presence of copper salts as co-catalysts. One limitation of this coupling is the alkyne source, in particular the use of volatile terminal alkynes. The decarboxylative Sonogashira reaction between aryl halides and alkynyl carboxylic acids has emerged as an alternative to the Sonogashira reaction, and terminal alkynes are replaced by the corresponding alkynyl carboxylic acids that are easily available and stable for handling and storage.A mild procedure of palladium and copper catalyzed decarboxylative cross-coupling reaction of aryl halides and alkynyl carboxylic acids has been developed. Low molecular weight acids, to introduce small building blocks, were specifically used. This methodology is easy to implement and uses common reactants and catalysts. |
| File Format | |
| Language | English |
| Publisher Date | 2016-01-01 |
| Access Restriction | Open |
| Subject Keyword | chim Chemical Sciences Organic chemistry |
| Content Type | Text |
| Resource Type | Poster |
