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| Content Provider | frontiers |
|---|---|
| Author | Kim, Junhyung Hwang, Kihwan Kwon, Hyun Jung Lee, Ji Eun Lee, Kyu Sang Choe, Gheeyoung Han, Jung Ho Kim, Chae-Yong |
| Abstract | Background: Grade 2/3 meningiomas have locally aggressive behaviors often requiring additional treatment plans after surgical resection. Herein, we explored the clinical significance of next-generation sequencing (NGS) in characterizing the molecular profiles of high-grade meningiomas. Methods: Patients with intracranial meningioma who underwent surgical resection in a single institution were retrospectively reviewed. Clinicopathologic relevance was evaluated using recurrence-free survival (RFS) as an outcome measure. NGS for the targeted gene regions was performed in 40 participants. Results: Among the 713 individuals in the study population, 143 cases (20.1%) were identified as having grade 2 or 3 meningiomas with a significantly lower female predominance. While the difference in RFS between grade 2 and 3 meningiomas was insignificant, a few conventional grade 2 cases, but with TERT promoter hotspot mutation, were highly progressive and refractory to the treatment. From the NGS study, recurrent mutations in TRAF and AKT1 were identified with a higher prevalence (17.5% and 12.5%, respectively) compared with grade 2/3 meningiomas reported in previous literature. However, their relations to other histopathologic properties or clinical factors were rarely observed. Conclusions: Grade 2/3 meningiomas show a broad spectrum of molecular profiles, as they have heterogeneous histologic characteristics. |
| ISSN | 2234943X |
| DOI | 10.3389/fonc.2022.885155 |
| Volume Number | 12 |
| Journal | Frontiers in Oncology |
| Language | English |
| Publisher Date | 2022-06-13 |
| Access Restriction | Open |
| Subject Keyword | Anaplastic meningioma Atypical meningioma Next-generation sequencing Meningioma TERT promoter mutation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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